| Students
know cells combine to form tissues that combine to form organs and
organ systems that are specialized to perform life functions. E/S
The smallest unit of life is a single cell. A single-celled organism
must perform all of the functions of life independently of other
cells. In contrast, multicellular organisms have differentiated
cells that perform specific tasks that collectively perform all
of the functions of life.
Levels of Organization
Multicellular organisms exhibit many levels of organization starting
with cells. Cells are differentiated, meaning that not all cells
are identical within an organism. Each cell has the same genetic
code (DNA) but not all genes are active within a cell. For example,
a skin cell has a different structure and function than a liver
cell. Therefore, these cells look different and perform a different
task.
One type of cells working together to perform a specific function
is called a tissue. Examples of tissue are muscle (Figure 3), nerve
(Figure 4), epithelial (Figure 5), and connective tissues. These
tissues are made of many cells performing a function together. Muscle
tissues have the ability to contract and relax performing movement,
nerve tissue responds to stimuli and conducts impulses, epithelial
cells provide a continuous protective barrier between the body and
the environment, and connective tissue supports and binds other
tissues.
The heart is an example of an organ. It is made up of several
types of tissues like muscle, nerve, and connective tissues working
together to move blood around the body.

Figure 6. The heart.
(From http://www.gwc.maricopa.edu/class/bio202/cyberheart/hartbak.htm)
The next level of hierarchy is the organ system. An organ system
is composed of several organs working together to perform a specific
function. The heart is part of the circulatory system which heart
works together with the veins, arteries, blood, and capillaries
to transport oxygen and nutrients to all of the cells in an organism
and carry away metabolic wastes.

Figure 7. The human circulatory
system.
(From. http://www.imcpl.org/kids/guides/health/circulatorysystem.html)
Finally, several organ systems working collectively comprise the
whole organism. Each system depends on the others to complete the
activities of life. For example, the circulatory system is responsible
for delivery of materials, including oxygen, around the body. Therefore,
the circulatory system is linked with the respiratory system which
absorbs oxygen from the air and transfers it to the bloodstream.

Figure 8. The whole human body.
(From http://americanhistory.si.edu/anatomy/
collection/nma03_collection_human.html)
To review, multicellular organisms have multiple levels of organization.
An organism is made up of several organ systems. Each organ system
is made up of several organs that work together. Each organ is made
up of several tissues working together. Finally, each tissue is
made up of similar cells working together. Figure 9 illustrates
this hierarchy within a frog starting with a muscle cell. This muscle
cell works with other muscle cells to form smooth muscle tissue.
The muscle tissue works with other tissues to form a heart which
combines with other organs to form the circulatory system. Finally,
the respiratory system works with other organ systems to form the
frog.

http://www.rpdp.net/sciencetips_v3/images/l8b4/L8B4_levels.gif
Figure 9. Levels of Hierarchy within
an Organism.
a. Organism = Frog (From http://sos.georgia.gov/state_symbols/state_amphibian.html)
b. Organ System = Circulatory System (From http://slohs.slcusd.org/pages/teachers/bsmith/
ZZ%20%20Folder/Ron's%20Biology
%20Web%20Page
/Biology/Frog%20Dissection/respiratory%20system.htm)
c. Organ = Heart (From http://slohs.slcusd.org/pages/teachers
/bsmith/ZZ%20%20Folder/Ron's%20Biology%20Web%20Page/Biology/
Frog%20Dissection/respiratory%20system.htm)
d. Tissue = Smooth Muscle (From http://www.ihcworld.com/imagegallery
/displayimage.php?album=3&pos=4)
e. Cell = Muscle Cell (From http://www.udel.edu/biology/Wags/histopage/
modelspage/smooth_muscle_fiber.GIF)
Human Organ Systems
There are several organ systems that comprise the human body. Each
organ system performs a function necessary for survival. However,
organ systems do not work in isolation. The organ systems must interact
with each other to complete whole organism activities necessary
to remain alive. For example, the circulatory system functions to
transports materials to body cells and remove metabolic wastes.
These transported materials may have origins in the respiratory
system (oxygen, carbon dioxide), endocrine system (hormones), digestive
system (nutrients), immune system (white blood cells), and the excretory
system (metabolic wastes).
The following table summaries the structure and function of the
major organ systems of the human body.
| Organ system |
Organs |
Function |
| Circulatory |
Heart, arteries, veins, blood |
Transports oxygen, hormones, and nutrients to cells and removes
metabolic wastes |
| Digestive |
Mouth, esophagus, stomach, intestines, liver, pancreas |
Breaks down food and absorbs nutrients |
| Endocrine |
Pituitary, adrenal, thyroid, hypothalamus, and others |
Coordinates the activities of the body including growth and
metabolism |
| Immune |
Lymph, lymph nodes and vessels, white blood cells |
Removes foreign bodies from the bloodstream
|
| Integumentary |
Skin hair, nails, sweat glands |
Provides barrier between body and outside environment |
| Muscular |
Skeletal muscle, cardiac muscle, smooth muscle |
Produces body movement |
| Nervous |
Nerves, sense organs, brain, spinal cord |
Relay electrical signals throughout the body, directs behavior
and movement |
| Reproductive |
Testes, ovaries, associated reproductive structures |
Carries out reproduction |
| Respiratory |
Lungs, nose, trachea |
Captures oxygen and exchanges gasses
|
| Skeletal |
Bones, cartilage, ligaments |
Provides protection and provides support for movement |
| Urinary |
Kidneys, bladder, urethra |
Removes metabolic wastes from the bloodstream and excrete
from the body |
For further detail on organ systems visit MS TIPS
Benchmark L.8.B.2
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Content Benchmark L.8.B.4
Students know cells combine to form tissues that combine to form
organs and organ systems that are specialized to perform life functions.
E/S
Common misconceptions associated with this benchmark
1.Students incorrectly believe that digestion is the process
that releases usable energy from food.
Students confuse digestion with cellular respiration. It is difficult
for students to understand that digestion is only the breakdown
of food, both mechanically and chemically, into absorbable substances
necessary for growth and maintenance. Digestion begins in the mouth
with chewing and the enzyme activity of saliva. Acid and different
enzymes in the stomach continue the breakdown of macromolecules.
The majority of digestion and absorption actually takes place in
the small intestine. Nutrients pass through the wall of the small
intestine and enter the blood stream. The large intestine absorbs
water and stores feces for elimination from the body. Carbohydrates
in the bloodstream are broken down into glucose and delivered to
every cell in the body. Energy is derived from the glucose at the
cellular level through the process of respiration.
For more information on digestion visit
http://digestive.niddk.nih.gov/ddiseases/pubs/yrdd/
For more information on cellular respiration visit
http://www.phschool.com/science/biology_place/biocoach/cellresp/intro.html
2.Students incorrectly believe that respiration is synonymous with
breathing.
Breathing refers to the process that brings about an exchange of
gases between the organism and its environment. Respiratory tissue
absorbs oxygen and expels carbon dioxide. On the other hand, respiration
refers to the process that releases energy from food substances
in living cells. At the primary level, students do not make the
distinction between breathing as a physical process and respiration
as a chemical process.
For further explanation of this misconception visit
http://www.ied.edu.hk/apfslt/v8_issue1/boohk/boohk3.htm
For more information on cellular respiration visit
http://www.biology.iupui.edu/biocourses/N100/2k4ch7respirationnotes.html
For more information on the process of breathing visit
http://yucky.discovery.com/flash/body/pg000138.html
3.Students incorrectly believe that organ systems work independently
of each other.
Students usually learn the body systems in isolation and memorize
the parts and function of each organ, but lack understanding of
how the systems work together. For example, the circulatory system
functions to transports materials to body cells and remove metabolic
wastes. These transported materials may have origins in the respiratory
system (oxygen, carbon dioxide), endocrine system (hormones), digestive
system (nutrients), immune system (white blood cells), and the excretory
system (metabolic wastes).
For information on how the body systems interact with the nervous
system visit http://faculty.washington.edu/chudler/organ.html
An article on how organ systems communicate can be found at http://www.merck.com/mmhe/sec01/ch001/ch001d.html
4.Students incorrectly think muscles are only used for voluntary
physical actions like walking, running, or throwing.
“Skeletal muscles are probably most familiar to middle school
students even though other types of muscles, cardiac and smooth,
are essential for life functions. The heart muscle is composed of
a different type of muscle cell (cardiac muscle cells) and beats
to move blood throughout the body. Smooth muscle cells line blood
vessels and the intestinal tract to help move blood or food through
those passages. The tongue is made up of muscle cells that enable
us to speak and is also an important part of the digestive system.”
An article on misconceptions associated with the muscular system
can be found at
http://science.education.nih.gov/supplements/nih6/Bone/guide/info_musculo_skin-a.htm
5.Students incorrectly think that muscles turn to fat if
you quit exercising.
Students believe that if they stop exercising their muscles will
turn into fat. Students must understand that muscle cells cannot
change into adipose (fat) cells and understand the definition of
a tissue. Cells are differentiated. This means that cells may differ
from one another in structure and function but they retain that
same function through out the life of the cell. Muscles cells and
fat cells may increase or decrease in volume or quantity due to
changes in nutrition and activity, but the cells do not convert
from one form to another.
The following link provides and explanation of different types
of human body cells http://www.cancerhelp.org.uk/help/default.asp?page=98
6.Students do not relate the concept of tissues, organs,
and organ systems to plants.
Students can easily identify roots, stems, and leaves in a plant
but do not understand that plants are also made of cells organized
into tissues, organs, and organ systems. For example, vascular plants
have a circulatory system composed of xylem (transports water from
the roots to the leaves) and phloem (transports sugars from the
leaves to the rest of the plant) tissues that work together to circulate
materials around a plant. Xylem is made up of two main types of
cells: tracheids and vessel elements. Xylem also contains other
kinds of cells, such as parenchyma, that function in structure and
storage. Phloem is made up of sieve tube cells and companion cells,
as well as parenchyma cells. Therefore, together xylem and phloem
comprise the circulatory system of a vascular plant.
For more information on the vascular system of plants visit http://www.emc.maricopa.edu
/faculty/farabee/BIOBK/BioBookPLANTANAT.html
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Content Benchmark L.8.B.4
Students know cells combine to form tissues that combine to form
organs and organ systems that are specialized to perform life functions.
E/S
Sample Test Questions
1st Item Specification: Know cells work together to form tissues, organs, and organ systems.
Depth of Knowledge Level 1
- Which of the following is the correct ranking of organizational hierarchy of organisms from simplest to most complex?
- cells, organs, tissues, organ systems, organisms
- cells, tissues, organs, organ systems, organisms
- tissues, cells, organs, organ systems, organisms
- tissues, organs, cells, organ systems, organisms
- A group of similar cells working together is a(n)
- cell.
- organ.
- tissue.
- organism.
Depth of Knowledge Level 2
- This diagram is of a human structure.
Diagram from: http://www.medicalook.com/human_anatomy/organs/Brain.html
Which of the following best describes the level of organization in the diagram above?
- Cell
- Organ
- Tissue
- Organ system
- There are four types of tissues that are made up of specialized cells. Which type of tissue is most affected by a disease that infects bone?
- Connective tissue
- Muscle tissue
- Nervous tissue
- Epithelial tissue
2nd Item Specification: Know the functions of organs and organ systems. (i.e. skeletal, muscular, digestive, circulatory, respiratory, nervous)
Depth of Knowledge Level 1
- What human body system breaks down food and absorbs nutrients?
- Digestive
- Endocrine
- Respiratory
- Skeletal
- What two body systems work together to produce movement?
- Circulatory and skeletal
- Muscular and digestive
- Respiration and nervous
- Skeletal and muscular
Depth of Knowledge Level 2
- Which of the following best explains the interaction between the circulatory system and the respiratory system?
- The respiratory system adds nutrients to the bloodstream which is delivered to cells.
- The respiratory system adds oxygen to the bloodstream which is delivered to cells.
- The bloodstream delivers oxygen to the lungs to be exhaled from the body.
- The bloodstream delivers nutrients to the lungs to be converted into carbon dioxide.
- Use the following diagram to answer the following.

Figure modified from free clip art website
http://school.discoveryeducation.com/clipart/category/scie.html
Which organ system in humans performs a similar function as shown in the plant above?
- Circulatory
- Respiration
- Digestion
- Excretory
3rd Item Specification: Know there are different types of cells within tissues, organs, and organ systems in the same organism designed to take on specialized tasks.
Depth of Knowledge Level 1
- Organs are made up of different types of tissues working together to perform specialized tasks. Which of the following tissues would NOT be found in the heart?
- Skeletal muscle tissue
- Cardiac muscle tissue
- Nerve tissue
- Vascular tissue
- What is the function of a specialized muscle cell?
- Transmits a signal to the brain to produce movement.
- Delivers oxygen to the muscle to produce movement.
- Contracts to produce movement.
- Expands to produce movement.
Depth of Knowledge Level 2
- Sickle Cell Anemia is a disease that causes red blood cells to change shape. A person with this disease would be
- unable to digest fats in their diet.
- tired due to decreased oxygen reaching their brains.
- unable to walk due to lack of muscular control.
- likely to get infections due to a damaged immune system.
- ALS, Amyotrophic lateral sclerosis, is a disease that affects the motor nerves of the human body. A person with this disease would be
- unable to digest fats in their diet.
- tired due to decreased oxygen reaching their brain.
- unable to walk due to lack of muscular control.
- likely to get infections due to a damaged immune system.
Constructed Response L.8.B.4
1. Answer the following questions regarding the human circulatory system.
- Describe the function of the circulatory system.
- List and describe the function the major organs in the circulatory system.
- Explain how the circulatory system interacts with the respiratory system within an organism to maintain homeostasis.
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Content Benchmark L.8.B.4
Students know cells combine to form tissues that combine to
form organs and organ systems that are specialized to perform life
functions. E/S
Answer to Sample Test Questions
- B, DOK Level 1
- C, DOK Level 1
- B, DOK Level 2
- A, DOK Level 2
- A, DOK Level 1
- D, DOK Level 1
- B, DOK Level 2
- A, DOK Level 2
- A, DOK Level 1
- C, DOK Level 1
- B, DOK Level 2
- C, DOK Level 2
Constructed Response L.8.B.4 Score Rubric:
3 points |
Response addresses all parts of the question clearly and correctly.
The function of the circulatory system is to transport oxygen to every cell in the body, to transport wastes for elimination from the body, and to move white blood cells around the body to attack pathogens.
Heart – a muscle that pumps blood throughout the body
Arteries – vessels that carry blood away from the heart to the lungs to pick up oxygen and then deliver that oxygen to every cell in body
Veins – carry deoxygenated blood back to the heart
Capillaries – very small blood vessels that act as connectors between veins and arteries.
Cells need oxygen for cellular respiration. The respiratory system draws oxygen out of the air. The circulatory system picks up the oxygen from the lungs and delivers it to the cells. |
2 points |
Response addresses all parts of the question and includes only minor errors. |
1 point |
Response does not address all parts of the question. |
0 points |
Response is totally incorrect or no response provided. |
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Content Benchmark L.8.B.4
Students know cells combine to form tissues that combine to
form organs and organ systems that are specialized to perform life
functions. E/S
Intervention Strategies and Resources
The following is a list of intervention strategies and resources
that will facilitate student understanding of this benchmark.
1.Online research/writing activity
This lesson asks students to “use the internet and library
resources to find out more about the effects of zero gravity and
space travel on body systems. Then create a brochure that explains
some of the technologies that allow people to live for extended
periods of time in space. This is a good chance to have students
write. They need to express an understanding of organ systems and
explain the effects that space travel would have on those systems.
The hook for this activity is students’ natural curiosity
of space.
You can access this activity at http://go.hrw.com/resources/go_sc/hst/ia/hstl22.htm
2.Online organ system game is appropriate
for middle school and English Language Learners
“This practice lesson introduces students to several organ
systems through an interactive online experience. The objective
of the lesson is for students to understand that there are different
systems within the body and that they work independently and together
to form a functioning human body. Through the use of an online interactive
activity, students learn about the concept of separate components
working together to build a body system. In addition, this lesson
focuses on activities to help students learn that body systems work
together to build the functioning human body. This lesson could
be used in conjunction with instruction on the human body and/or
systems.” http://ohiorc.org/record/3572.aspx
You can access the lesson plan page through the following link
http://www.sciencenetlinks.com/lessons.cfm?BenchmarkID=11&DocID=385
You can directly access the game at
http://www.sciencenetlinks.com/interactives/systems.html
3.Discover Kids Website “Yucky, Gross,
and Cool Body”
Nothing motivates a middle school student more than an explanation
of belches, snot, and ear wax. This website lets students “find
out all about the human body with Wendell the Worm, Yucky's Ace
Reporter.” The website allows students to choose a body function
or a body system to investigate. The reading level is appropriate
for middle school students and the explanations are grounded in
science.
You can access this site at http://yucky.discovery.com/flash/body/index.html
4.Neuroscience for Kids
“Discover the exciting world of the brain, spinal cord, neurons,
and the senses. Use the experiments activities and games to help
you learn about the nervous system. There are plenty of links to
other web sites for you to explore.” This is a great website
written for middle aged students to investigate the nervous system.
Parts of the website are available in Spanish and other languages.
You can access this website at http://faculty.washington.edu/chudler/neurok.html
5.Welcome to the Organ Systems
“This "Organ Systems" module has five units of instruction
that focus on the main classes of functions that a body must perform.
Rather than just naming organs of the body and what they do, we
present a perspective on the body as a coordinated group of systems
that must do certain things correctly in order to survive and thrive.”
This is a great website for average to above average middle school
students. It has five modules including: Bodily Defenses, Digestion,
Detoxification, Gas Exchange, and Coordination and Control. Each
module starts with an introduction with module objectives. Then
each module covers why each system is important, how we learned
about each system’s structure and function, historical perspective,
and common hazards. Each module also contains several activities
that teachers can use to reinforce the concepts presented. Lastly,
each module contains a “Self-Study Game”. A plug-in
must be downloaded to run the Self-Study Game.
There is also a teacher companion site. An account must be activated
to use the teacher pages.
You can access this website at
http://peer.tamu.edu/curriculum_modules/OrganSystems/index.htm
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